What are the risks of amphetamine and methamphetamine abuse?

Amphetamine and methamphetamine abuse can cause serious cardiovascular problems, visual hallucinations, tremors, loss of coordination, and, in extreme cases, death from stroke or heart failure.

Furthermore, a recent study found that 26 former methamphetamine users showed losses of neurons and other brain chemical abnormalities even after abstaining for an average of four months. The report concluded that these glitches lend evidence for long-term cognitive problems, and the death of neurons that release dopamine may contribute to ongoing depression in chronic users who have kicked the habit.

Chronic intravenous abuse can cause permanent blood vessel damage, and needle sharers are at a greater risk for contracting infectious diseases such as AIDS. Paranoia, anxiety, and sudden bursts of aggression may also occur in those addicted to injected methamphetamine (perhaps because it is often mixed with PCP).

These psychological symptoms can lead to homicidal or suicidal thoughts, and anecdotal evidence points to methamphetamine abusers showing more violent tendencies than cocaine abusers.

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What is methamphetamine?

Methamphetamine is very similar to amphetamine, but has an even stronger effect on the central nervous system. It is typically produced in clandestine laboratories from over-the-counter ingredients and sold as "speed", "meth" and "crank" in its powder form. Methamphetamine is also sold in a smokable (and injectable) form of clear chunky crystals called "ice", "crystal" or "glass". It is a popular drug on the dance club scene, and many college students - perhaps unaware of the risks - have also taken speed to stay awake writing papers and preparing for exams.

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What are amphetamines?

Amphetamines are manufactured central nervous system (CNS) stimulants -- drugs that increase your heart rate and give you more energy and stamina. Over the years, doctors have used them to treat a laundry list of ailments, including hiccups, seasickness, schizophrenia, and caffeine dependence, and during World War II they were distributed to servicemen to keep them alert for combat. Pseudoephedrine is the active ingredient in many over-the-counter nasal decongestants. Today, they are most often used to treat narcolepsy and attention deficit hyperactivity disorder (ADHD). Common amphetamine preparations for these disorders include methylphenidate and detroamphetamine compounds.

Others were developed specifically for the illegal drug market and have been sold on the street, usually as pills or in powder form, under names like speed, or "white crosses". Along with cocaine and Ecstasy, amphetamines and methamphetamine are the most widely used illegal stimulants. Amphetamines increase your heart rate and blood pressure, which can result in heart attack or stroke. Speed bought on the street carries an added risk common to all black-market drugs -- you never know quite what you're getting. Preparations may vary wildly in concentration, or be laced with other harmful drugs, such as PCP or Ecstasy. However, the danger is not confined to illicit amphetamines -- over-the-counter diet pills containing phenylpropanolamine (PPA) have also been linked to stroke in otherwise healthy people. And ephedrine, a CNS stimulant found in many diet pills, has been linked to a variety of adverse effects, including heart attacks and strokes.

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